DXSet program searches for doublets of peaks in a series of mass list text files. It is designed primarily for the analysis of sets of MS spectra, for example, LC/MALDI chromatographic runs. Mass lists have to be stored as single columns of values in .txt files. DX_Controls.txt contains control parameters for the program in four lines: 1. Mass difference value has to occupy leftmost position of the first string followed by space. 2. Second string of the DX_Control.txt file contains the tolerance value in Daltons for determining of doublets. 3. Third line contains a submask of masslist filenames (common part for all masslist filenames) followed by a space. 4. Fourth line contains ABI MALDI plate type (16x12, 8x24, or 16x24). All files need to be in the same directory. Total mass list will be stored in associated with mass lists Total _.txt result file. Doublets if found will be stored in associated with mass lists Total _DX.txt result file.